Sub-Equimolar Hydrolysis and Condensation of Organophosphates
نویسندگان
چکیده
منابع مشابه
Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase.
Phosphotriesterase (PTE) from Pseudomonas diminuta is a zinc metalloenzyme that hydrolyzes a variety of organophosphorus compounds. The kinetic parameters of Zn/Zn PTE, Cd/Cd PTE, and a mixed-metal Zn/Cd hybrid PTE were obtained with a variety of substrates to determine the role of each metal ion in binding and catalysis. pH-rate profiles for the hydrolysis of diethyl p-nitrophenyl phosphate (I...
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A rational design of paraoxonase 1 based on molecular docking discovered H115W/T332S and I74F/H115W/T332S mutants exhibited a 40-fold increase in catalytic efficiency (kcat/Km) toward the hydrolysis of two toxic and popular organophosphates (diethyl-paraoxon and dimethyl-paraoxon). Moreover, the conversion of the paraoxons (741.3-825.6 mg L(-1)) by the evolved mutants was 42-60-fold faster than...
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ژورنال
عنوان ژورنال: ChemistrySelect
سال: 2016
ISSN: 2365-6549
DOI: 10.1002/slct.201600498